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Ezetimibe is primarily metabolized in the small intestine and liver via glucuronide conjugationa phase II reactionwith subsequent biliary and renal excretionMinimal oxidative metabolisma phase I reactionhas been observed in all species evaluated.

You should not use ezetimibe with astatincholesterol medicineZocorLipitorCrestorand othersif:

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If cholelithiasis is suspected in a patient receiving ZETIA and fenofibrategallbladder studies are indicated and alternative lipid-lowering therapy should be consideredsee ADVERSE REACTIONS and the product labeling for fenofibrate

Store at room temperatureStore in a dry placeDo not store in a bathroomKeep all drugs in a safe placeKeep all drugs out of the reach of children and petsThrow away unused or expired drugsDo not flush down a toilet or pour down a drain unless you are told to do soCheck with your pharmacist if you have questions about the best way to throw out drugsThere may be drug take-back programs in your area.

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